FWIW I used WEDI on some second floor showers a few years ago. WEDI is a great product. I bought a full pallet of it and by the time I paid shipping the sheets cost me about $21 per for 3X5's, double what Hardi costs.
I too thought WEDI would take the world by storm but the truth is I couldn't get anyone around here to give it a second look after they heard what it cost. I love the stuff and it is the only true 100% waterproof tilebacker on the market that I'm aware of. I was able to carry eight sheets at a time up the steps of this house, try doing that with cement board.
WEDI easily cuts and trims with a utility knife and you can place it on the wall and nail it with no effort.
If the cost were somehow competitive it would fly much easier.
I'm not at all in favor of placing any cement board on a concrete floor, it just presents too many new problems but in the case of WEDI I would try it. Especially as a thermal barrier under a heat system.
