I have viewed the info on the Schluter system and was wondering if anyone has used this in a mobile home.

Never have, but considering how some of them are built, I would make certain all the framing was rock-solid before I started any tile installation.

If the house was ever moved, there might be some grout cracking in the corners, but that's easily fixable.

I think the only other adjustment would be changing the drain size from 1 1/2" to 2". Don't know any other reason why it couldn't work.