They will definitely hold up once the tile is on. I saw a picture of one with a forklift parked on it, and everything was still intact.
The benefits are relative ease and speed of installation. However, like Pete said, if your drain is off center, or you have to cut the tray down to fit your space, you've spent almost as much time as it takes to do a mud floor, and you've spent waaaay more money.
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The top ten reasons to procrastinate:
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